|
KMID : 0665420200350050478
|
|
Korean Journal of Food Culture
2020 Volume.35 No. 5 p.478 ~ p.482
|
|
|
Protective Effect of Gryllus Bimaculatus Methanol Extract on UVB-induced Photoaging in Human Skin Fibroblasts
|
|
Jeong Taek-Young
Yu Myeong-Nam
Heo Hui-Jin
Yang Jin-Woo
Jeong Heon-Sang
Lee Jun-Soo
|
|
|
Abstract
|
|
|
|
We evaluated the protective effects of cricket methanol extract (CME) on ultra-violet B (UVB)-induced photoaging inhuman skin fibroblasts. The fibroblast cells were treated with 10, 50, and 100 μg/mL of CME for 24 h, and then exposedto UVB (30 mJ/cm2). CME showed a dose-dependent cytoprotective effect without any observable cytotoxicity. CMEreduced UVB-induced production of reactive oxygen species (ROS) by 34.4, 34.9, 40.6% at concentrations of 10, 50, 100μg/mL respectively. CME inhibited the release of matrix metalloproteinase (MMP) 1 and 3. Furthermore, CME also reducedUVB-induced collagen degradation in the fibroblast cells. Taken together, our data suggests that CME has a significantprotective effect on UVB-induced photoaging of the skin. This benefit occurs through multiple mechanisms. The results alsosuggest a potential role for CME as an ingredient in anti-photoaging cosmetic products in the future.
|
|
|
KEYWORD
|
|
|
Gryllus bimaculatus, fibroblast, photoaging, collagen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|